Dr. Renu Mohan
Research expertise Design and development of anticancer agents, biophysical and biochemical characterization of protein-protein and protein-ligand interactions, spectroscopy, single molecule analysis, real time imaging (in vitro and in cells), microscopy (TIRF, confocal, fluorescence, DIC, electron microscopy), image analysis, in vivo and in vitro reconstitution of protein dynamics, 3D in vitro culture, RNAi technology.
2000-2002 MSc Biotechnology, Indian Institute of Technology (IIT) Delhi, India Project Title: Degradation of fatty acids by methanogens.Effluents from diary industry contain heavy chain fatty acids and hydrocarbons which causes environmental toxicity. My study indicated that certain species of methanogenic bacteria can efficiently degrade the heavier hydrocarbons into biodegradable small chain fatty acids.
2003-2008 PhD. Indian Institute of Technology (IIT) Bombay, India. Thesis Title: Perturbation of microtubule assembly dynamics-A possible mechanism of antiproliferative activity of sulfonamides, estramustine and conjugated nitroalkenes.
2010-2013 Post doctoral fellow, Cell Biology Department, Utrecht University, Utrecht, Netherlands and Erasmus Medical Centre, Rotterdam, Netherlands. Project Title: Mechanisms and functions of microtubule plus end tracking proteins in mammalian cells: development of inhibitory strategies.
- 2014 Research Associate; Inter University Centre for Genomics and Gene Technology, University of Kerala, Thiruvananthapuram Establish three-dimensional in vitro tumour spheroids using different hydrogels and scaffold
2015DBT Ramalingaswamy Fellow, Sri Chitra Tirunal Institute for Medical Sciences & Technology, Poojappura, Thiruvananthapuram.
Award period: 2015 – 2020, Award amount: $130815
Project Title: How actin/Intermediate filament structures within the cell are regulated by changes in microtubule dynamics: Role of microtubule associated proteins and crosslinking proteins in maintaining cytoskeletal networking
As Guest Lecturer for BSc Biotechnology, Government College Karyavattom (June 2009-August 2009).
Teaching Assistant for BTech students at IIT Bombay (June 2003-December 2003)
- Mohan R*, Mohan N and Vaikkath D. Hyaluronic acid dictates chondrocyte morphology and migration in collagen-hyaluronic acid composite gels.(Corresponding author, manuscript submitted)
- Guesdon A, Bazile F, Buey RM, Mohan R, Monier S, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO and Chrétien EB1interacts with outwardly curved and straight regions of the microtubule lattice. Nature Cell Biology 2016, 18(10), 1102-8.(Impact factor:20; citations:10)
- Mohan R* and John A. Microtubule Associated Proteins (MAPs) as direct cross linkers of actin and microtubule cytoskeleton. Review IUBMB Life 2015 67(6):395-403. (*Corresponding Author). (Impact Factor:3.1; citations:20)
- Mohan R, Katrukha E, Doodhi H, Smal I, Meijering E, Kapitein CL, Steinmetz MO, Akhmanova A. End Binding proteins sensitize microtubules to the action of microtubule targeting agents. Proc Natl Acad Sci USA 2013; 110(22):8900-5.(Impact Factor:9.8, citations:44)
- Jiang K, Hua S, Mohan R, Grigoriev I, Yau KH, Liu Q, Katrukha E, Altelaar AFM, Heck AJR, Hoogenraad CC, Akhmanova A. Microtubule minus end stabilization by polymerization driven CAMSAP deposition. Developmental Cell, 2014, 28; 3, 2014, Pages 295-309) (Impact Factor:13.0, citations: 76
- Asthana J, Kapoor S, Mohan R, Panda D. Inhibition of HDAC6 deacetylase activity increases its binding with microtubules and suppresses microtubule dynamic instability in MCF-7 cells. J Biol Chem. 2013 (288(31):22516-26) (Impact Factor: 4.8, citations:14)
- Ray S, Mohan R, Singh JK, Samantaray MK, Shaikh MM, Panda D, Ghosh P. Anticancer and antimicrobial metallopharmaceutical agents based on palladium, gold, and silver N-heterocyclic carbene complexes. J Am Chem Soc. 2007, 129, 15042-15045. (Impact Factor:12.1, citations:409
- Mohan R, Banerjee M, Ray A, Manna T, Wilson L, Owa T, Bhattacharyya B, Panda D. Antimitotic sulfonamides inhibit microtubule assembly dynamics and cancer cell proliferation. Biochemistry. 2006, 45, 5440-5449. (Impact Factor:3.4, citations:62)
- Rastogi N, Mohan R, Panda D, Mobin SM, Namboothiri IN. Synthesis and anticancer activity studies of alpha-aminoalkylated conjugated nitroalkenes. Org Biomol Chem. 2006, 4, 3211-3214. (Impact Factor:3.5, citations:40)
Buey RM, Sen I, Kortt O, Mohan R, Gfeller D, Veprintsev D, Kretzschmar I, Scheuermann J, Neri D, Zoete V, Michielin O, de Pereda JM, Akhmanova A, Volkmer R, Steinmetz MO. Sequence determinants of a microtubule tip localization signal (MtLS).J Biol Chem. 2012;287(34):28227-4. (Impact Factor:4.8, citations:29)
Pagano A, Honoré S,Mohan R, Berges R, Akhmanova A, Braguer D. Epothilone inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends. Biochem Pharmacol. 2012;84(4):432-43. (Impact Factor:4.7, citations:27)
- Buey RM, Mohan R, Leslie K, Walzthoeni T, Missimer JH, Menzel A, Bjelic S, Bargsten K, Grigoriev I, Smal I, Meijering E, Aebersold R, Akhmanova A, Steinmetz MO. Insights into EB structure and the role of its C-terminal domain in discriminating microtubule tips from lattice. Mol Biol Cell. 2011 22(16):2912-23. (Impact Factor:4.9, citations:49)
- Mohan R and Panda D. Kinetic stabilization of Microtubule Dynamics by Estramustine is Associated with Tubulin Acetylation, Spindle Abnormalities and Mitotic Arrest. Cancer Res. 2008, 68 (15), 6181-6189. (Impact Factor:9.3, citations:48)
- Singh P, Rathinasamy K, Mohan R, Panda D. Microtubule assembly dynamics: an attractive target for anticancer drugs. IUBMB Life. 2008; 60(6):368-75. Review. (Impact Factor:2.8, citations:119)
- Jaiswal R, Beuria TK, Mohan R, Mahajan SK, Panda D. Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ. Biochemistry. 2007, 46, 4211-4220. (Impact Factor:3.4, citations:110)
- Mohan R, Rastogi N, Namboothiri IN, Mobin SM, Panda D. Synthesis and evaluation of alpha-hydroxymethylated conjugated nitroalkenes for their anticancer activity: inhibition of cell proliferation by targeting microtubules. Bioorg Med Chem. 2006, 14, 8073-8085. (Impact Factor:3.2, citations:50)
- Dadwal M, Mohan R, Panda D, Mobin SM, Namboothiri IN. The Morita-Baylis-Hillman adducts of beta-aryl nitroethylenes with other activated alkenes: synthesis and anticancer activity studies. Chem Commun (Camb).2006, 3, 338-340. (Impact Factor:6.7, citations:35)
Awards And Recognition